high quality transgenerational impact of dehp on body weight
Transgenerational impact of DEHP on body weight of Drosophila
In the present study, to clarify the transgenerational impact of DEHP exposure on body weight, by using Drosophila model, we found that long-term exposure of DEHP to the parents but not short-term led to change of offspring body weight. Furthermore, doses of DEHP is also crucial. High doses (above 0.5%) but not low concentrations of DEHP
Direct and transgenerational effects of low doses
While the doses used in this study were relatively high (150 and 200 mg/kg body weight), these results were the first evidence of a transgenerational effect of DEHP exposure on behavior. In the present report, we evaluated three low doses of DEHP: 5, 40, and 400 μg/kg, all of which are below the no observed effect level (NOAEL, 4.8 mg/kg/day
Multi and transgenerational epigenetic effects of di-(2
In the F3 generation, DEHP exposure caused a significant decrease after both low and high concentration treatment in PND 8, indicating transgenerational effect of DEHP on DNA methylation. However, less significant decrease was observed in PND 60 high dosage group, suggesting a mechanism to reverse epigenetic changes in ancestors due to external
(PDF) Direct and transgenerational effects of low doses
Direct and transgenerational effects of low doses of perinatal Di-(2-ethylhexyl) phthalate (DEHP) on social behaviors in mice February 2017 PLoS ONE 12(2):e0171977
Germline-dependent transmission of male reproductive traits
Further, a number of studies have assessed the transgenerational impact of prenatal DEHP exposure on reproductive function and reported that DEHP induces reproductive dysfunction in the F2 and F3
Prenatal exposure to di(2-ethylhexyl) phthalate disrupts
Our data showed that DEHP exposure decreased body weight in the F2 generation at PNDs 8 and 21, but it did not affect body weight in the F1 and F3 generations. This is in contrast to a previous study in which prenatal exposure to a phthalate mixture (200 μg/kg/day and 200 mg/kg/day) increased body weight in the F2 generation of female mice [ 46 ].
Transgenerational epigenetic effects from male exposure to
Transgenerational inheritance of phenotypic effects from exposure to A1211 has been reported by others ; these effects were not always observed in the directly exposed F1 offspring, but emerged in F2 and F3 generations. Proof of epigenetic involvement has been demonstrated by Gillette et al. A1221-induced aberrances in the epigenome of sperm
Maternal exposure to di(2-ethylhexyl)phthalate (DEHP
the plasticizer di(2-ethylhexyl)phthalate (DEHP) at environmental doses promotes transgenerational effects on reproductive health in female offspring, as adults, over three generations in the mouse. Gestating F0 mouse dams were exposed to 0, 0.05, 5 mg/kg/day DEHP in the diet from gestational day 0.5 until the end of lactation.
2017 Annual Report | Novel Methods to Assess the Effects
In the F2 generation, exposure to DEHP decreased body and organ weights, dysregulated folliculogenesis, and disrupted serum progesterone levels. In the F3 generation, DEHP exposure accelerated folliculogenesis. These data suggest that prenatal exposure to DEHP leads to adverse multigenerational and transgenerational effects on ovarian function.
Transgenerational Effects of Di (2-Ethylhexyl) Phthalate
DEHP Administration from GD 8 to 17 of Lactation Had No Effect on Maternal Weight or Weight Gain during Dosing or Litter Size at 2 days of Age, but Reduced AGD and Body Weight in 2-Day-Old Male Rat Pups and Induced Female-Like Areolas/Nipples in 13-Day-Old...
2013 Annual Report | Novel Methods to Assess the Effects
The results indicate that for body weights as well as testis-to-body weight ratios, the F1 and F2 males were not different among the treatment groups, but the testis-to-body weight ratio of the BPA-50 μg/kg/day males was significantly higher than those of DES, BPA-0.5 μg/kg/day and BPA-20 μg/kg/day males (p < 0.005).
Transgenerational Glucose Intolerance With Igf2/H19
Body weight and the ratio of pancreas weight to body weight in F1 and F2 offspring Intrauterine hyperglycemia induced transgenerational transmission of glucose intolerance and abnormal insulin level. Blood glucose levels of all the 3- and 8-week-old F1-GDM and F2-GDM offspring did not differ from those in the corresponding controls in either