disulfiram (tetraethylthiuram disulfide
Disulfiram | C10H20N2S4
Disulfiram, the corresponding disulfide of diethyldithiocarbamate, was effective at concentrations 1,000 times lower (1X10-6 vs 1X10-3 M). Disulfiram, but not diethyldiethiocarbamate, reacted very efficiently with synaptosomal protein thiols; both diethyldithiocarbamate and disulfiram induced uptake inhibition could be reversed by the thiol
Tetraethylthiuram disulfide ≥97.0% (S) | TETD
Tetraethylthiuram disulfide ≥97.0% (S) Synonym: Bis(diethylthiocarbamoyl) disulfide, Bis(diethylthiocarbamyl) disulfide, Disulfiram, TETD CAS Number 97-77-8. Linear Formula (C 2 H 5) 2 NCSS 2 CSN(C 2 H 5) 2. Molecular Weight 296.54 . Beilstein/REAXYS Number 1712560 . EC Number 202-607-8. MDL number MFCD00009048.
The synthesis of disulfiram, originally known as tetraethylthiuram disulfide, was first reported in 1881. By around 1900, it was introduced to the industrial process of Sulfur vulcanization of rubber and became widely used.
Many patients find disulfiram a "game-changing" Lyme treatment
Liegner KB. Disulfiram (Tetraethylthiuram Disulfide) in the Treatment of Lyme Disease and Babesiosis: Report of Experience in Three Cases. Antibiotics (Basel).2019 May 30;8(2). pii: E72. doi: 10.3390/antibiotics8020072. Shen Y, Lindemeyer AK, Gonzalez C, et al. Dihydromyricetin as a novel anti-alcohol intoxication medication.
Disulfiram (Tetraethylthiuram disulfide) | Aldehyde
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. - Mechanism of Action & Protocol.
TETRAETHYLTHIURAM DISULFIDE (DISULFIRAM)
tetraethylthiuram disulfide: product identification. cas no. 97-77-8: einecs no. 202-607-8: formula [(c 2 h 5) 2 ncs 2-] 2: mol wt.
Using Disulfiram to Treat Alcoholism and Alcohol Abuse
The History of Disulfiram. In the 1930s, workers in the rubber industry noticed they were becoming sick after drinking alcohol. These workers were dealing with tetraethylthiuram disulfide. In the later 1940s, when disulfiram was given in a study on stomach ailments, those who consumed alcohol also became ill.
Disulfiram (Tetraethylthiuram Disulfide) in the Treatment
Disulfiram (Tetraethylthiuram Disulfide) in the Treatment of Lyme Disease and Babesiosis: Report of Experience in Three Cases Antibiotics (Basel) . 2019 May 30;8(2):72. doi: 10.3390/antibiotics8020072.
Disulfiram: Alcoholism Treatment Medication - Addiction Center
Disulfiram (tetraethylthiuram disulfide or Antabuse) has been prescribed for the treatment of alcohol use disorders (AUDs) in the United States for more than 65 years and is currently used by more than 200,000 Americans. Disulfiram works by interfering with the body’s digestion and absorption of alcohol, creating a series of highly unpleasant
TETRAETHYLTHIURAM DISULFIDE is sensitive to light. This compound is incompatible with strong acids, strong oxidizers and nitrosating agents (e.g. N-Nitrosodiphenylamine). (NTP, 1992).
Disulfiram | C10H20N2S4
Disulfiram is a carbamate derivative used as an alcohol deterrent.; Target: Dopamine ?-hydroxylase; Disulfiram is a drug used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. MedChem Express HY-B0240: Dopamine ?-hydroxylase MedChem Express HY-B0240: Enzymes Tocris Bioscience 3807
Disulfiram - Registration Dossier - ECHA
Tetraethylthiuram disulfide is expected to be rapidly degraded in water/sediment systems considering its potential for hydrolysis (especially under neutral and alkaline conditions, with half-lives of 3.5 days and 6.9 hours, respectively; Norris, 1991) and photolysis in water (half-life < 10 hours; Norris, 1990, Knoch, 1994).