high quality tissue transglutaminase expression is necessary

  • ttga - clinical: tissue transglutaminase antibody, iga, serum

    TTGA - Clinical: Tissue Transglutaminase Antibody, IgA, Serum

    If total IgA is normal and tissue transglutaminase (tTG)-IgA is negative, there is a low probability of the patient having celiac disease and a biopsy may not be necessary. If serology is negative or there is substantial clinical doubt remaining, then further investigation should be performed with endoscopy and bowel biopsy.

  • tissue transglutaminase

    Tissue transglutaminase

    Tissue transglutaminase (abbreviated as tTG or TG2) is a 78-kDa, calcium-dependent enzyme (EC 2.3.2.13) of the protein-glutamine γ-glutamyltransferases family (or simply transglutaminase family).

  • tissue transglutaminase expression is necessary for adhesion

    Tissue transglutaminase expression is necessary for adhesion

    Tissue transglutaminase (TG2) is the ubiquitously expressed member of transglutaminase family and shown to play a critical role in the development and progression of drug resistance malignancies. We have previously showed the association of TG2 upregulation with progression and metastasis of renal cell carcinoma (RCC) and low disease-free survival.

  • tissue transglutaminase expression promotes cell attachment

    Tissue transglutaminase expression promotes cell attachment

    On the other hand, the high expression of TG2 in metastatic breast cancer cells may explain their higher apoptotic threshold, an important characteristic of metastatic cancer cells that enables

  • the function of tissue transglutaminase in celiac disease

    The function of tissue transglutaminase in celiac disease

    Tissue transglutaminase expression is evident at the level of muscularis mucosae and of pericryptal fibroblasts. A spatial relationship between extracellular tTG, DQ-expressing cells and T-cells was found in the subepithelial region of intestinal biopsy specimens of untreated celiac patients [36] , and the presence of gluten-tTG supramolecular

  • transglutaminase and coeliac disease: endomysial reactivity

    Transglutaminase and coeliac disease: endomysial reactivity

    Tissue transglutaminase (tTG) has recently been identified as the autoantigen for endomysial antibodies (EMA), the serological hallmark of coeliac disease (CoD) . On clinical grounds this has led to the development of a new, economical and fairly accurate ELISA test [ 1 – 4 ].

  • ttga - clinical: tissue transglutaminase antibody, iga, serum

    TTGA - Clinical: Tissue Transglutaminase Antibody, IgA, Serum

    If total IgA is normal and tissue transglutaminase (tTG)-IgA is negative, there is a low probability of the patient having celiac disease and a biopsy may not be necessary. If serology is negative or there is substantial clinical doubt remaining, then further investigation should be performed with endoscopy and bowel biopsy.

  • tissue transglutaminase expression and activity in normal

    Tissue Transglutaminase Expression and Activity in Normal

    Transglutaminase enzymes are encoded by a group of genes that are structurally and functionally related. 12 Family members include keratinocyte transglutaminase (TGM1), tissue transglutaminase (TGM2), epidermal transglutaminase (TGM3), prostate transglutaminase (TGM4), TGM X (TGM5), TGM Y (TGM 6), TGM Z (TGM 7), and factor XIII-A subunit

  • tissue transglutaminase

    Tissue transglutaminase

    Tissue transglutaminase (abbreviated as tTG or TG2) is a 78-kDa, calcium-dependent enzyme (EC 2.3.2.13) of the protein-glutamine γ-glutamyltransferases family (or simply transglutaminase family).

  • tissue transglutaminase expression is necessary for adhesion

    Tissue transglutaminase expression is necessary for adhesion

    Tissue transglutaminase (TG2) is the ubiquitously expressed member of transglutaminase family and shown to play a critical role in the development and progression of drug resistance malignancies. We have previously showed the association of TG2 upregulation with progression and metastasis of renal cell carcinoma (RCC) and low disease-free survival.

  • tissue transglutaminase (ttg) antibody, iga | arup lab test

    Tissue Transglutaminase (tTG) Antibody, IgA | ARUP Lab Test

    Presence of the tissue transglutaminase (tTG) IgA antibody is associated with glutensensitive enteropathies such as celiac disease and dermatitis herpetiformis. tTG IgA antibody concentrations greater than 40 U/mL usually correlate with results of duodenal biopsies consistent with a diagnosis of celiac disease.

  • tissue transglutaminase expression promotes cell attachment

    Tissue transglutaminase expression promotes cell attachment

    To test the hypothesis that TG2 expression plays a role in conferring metastatic phenotype to breast cancer cells, we used two MDA-MB231-derived sublines (MDA231/cl.9 and MDA231/cl.16) that were

  • expression and rapid purification of highly active

    Expression and rapid purification of highly active

    The establishment of an efficient expression system of the recombinant mammalian tissue-type transglutaminase would allow the enzyme to be obtained in the high yield and purity that are essential to the structure/function studies required for mechanistic studies and the subsequent development of mechanism-based inhibitors.

  • ttga - clinical: tissue transglutaminase antibody, iga, serum

    TTGA - Clinical: Tissue Transglutaminase Antibody, IgA, Serum

    If total IgA is normal and tissue transglutaminase (tTG)-IgA is negative, there is a low probability of the patient having celiac disease and a biopsy may not be necessary. If serology is negative or there is substantial clinical doubt remaining, then further investigation should be performed with endoscopy and bowel biopsy.

  • tissue transglutaminase antibody levels predict iga deficiency

    Tissue transglutaminase antibody levels predict IgA deficiency

    Objective: Measuring serum tissue transglutaminase immunoglobulin A (tTG IgA) levels is the most widely used screening test for coeliac disease. However, given an increased prevalence of IgA deficiency among coeliac patients there is a risk of false negative results.

  • anti-tissue transglutaminase antibody - rochester, ny

    Anti-tissue Transglutaminase Antibody - Rochester, NY

    The higher the levels of anti-tissue transglutaminase antibodies in your blood, the more likely it is that you have it or a related disorder. Younger children are an exception to this rule. A test may come back negative even if the child has celiac disease.

  • tissue transglutaminase

    Tissue transglutaminase

    Tissue transglutaminase (abbreviated as tTG or TG2) is a 78-kDa, calcium-dependent enzyme (EC 2.3.2.13) of the protein-glutamine γ-glutamyltransferases family (or simply transglutaminase family).

  • celiac disease antibody tests | lab tests

    Celiac Disease Antibody Tests | Lab Tests

    Antibodies against native gliadin are not recommended for the detection of celiac disease (CD). The AGA test has a low diagnostic accuracy and is considered outdated. Immunoglobulin A (IgA) anti-tissue transglutaminase (tTG) antibody is the preferred single test for the serologic diagnosis of CD in individuals over the age of 2 years.

  • blood test: tissue transglutaminase iga, igg

    Blood Test: Tissue Transglutaminase IgA, IgG

    Blood Test: Tissue Transglutaminase IgA, IgG. What It Is. A tissue transglutaminase (tTG) IgA and/or IgG test is used as part of an evaluation for certain autoimmune conditions, most notably celiac disease. An autoimmune disease can occur when the body’s immune system mistakenly perceives a nonthreatening substance.

  • blood test: tissue transglutaminase iga, igg (for parents

    Blood Test: Tissue Transglutaminase IgA, IgG (for Parents

    A tissue transglutaminase IgA (tTg-IgA) test is used to help doctors diagnose celiac disease. Celiac disease is an autoimmune disorder in which the immune system mistakenly thinks that gluten — a protein in wheat, barley, rye, and oats — is a foreign invader.

  • ttga - clinical: tissue transglutaminase antibody, iga, serum

    TTGA - Clinical: Tissue Transglutaminase Antibody, IgA, Serum

    The finding of tissue transglutaminase (tTG)-IgA antibodies is specific for celiac disease and possibly for dermatitis herpetiformis. For individuals with moderately to strongly positive results, a diagnosis of celiac disease is likely and the patient should undergo biopsy to confirm the diagnosis.

  • blood test: tissue transglutaminase iga, igg (for parents

    Blood Test: Tissue Transglutaminase IgA, IgG (for Parents

    A tissue transglutaminase IgA (tTg-IgA) test is used to help doctors diagnose celiac disease. Celiac disease is an autoimmune disorder in which the immune system mistakenly thinks that gluten — a protein in wheat, barley, rye, and oats — is a foreign invader.

  • 164640: tissue transglutaminase (ttg), iga | labcorp

    164640: Tissue Transglutaminase (tTG), IgA | LabCorp

    Studies have demonstrated that IgA endomysial antibody tests have >99% specificity for gluten-sensitive enteropathy. 1 Recently, the endomysial antigen has been identified as the protein cross-linking enzyme known as tissue transglutaminase (tTG). 2

  • tissue transglutaminase

    Tissue transglutaminase

    Tissue transglutaminase (abbreviated as tTG or TG2) is a 78-kDa, calcium-dependent enzyme (EC 2.3.2.13) of the protein-glutamine γ-glutamyltransferases family (or simply transglutaminase family).

  • blood test: tissue transglutaminase iga, igg

    Blood Test: Tissue Transglutaminase IgA, IgG

    A tissue transglutaminase IgA (tTg-IgA) test is used to help doctors diagnose celiac disease. Celiac disease is an autoimmune disorder in which the immune system mistakenly thinks that gluten — a protein in wheat, barley, rye, and oats — is a foreign invader.

  • anti-tissue transglutaminase antibody - rochester, ny

    Anti-tissue Transglutaminase Antibody - Rochester, NY

    Anti-tissue Transglutaminase Antibody Does this test have other names? IgA anti-tissue transglutaminase, IgA Anti-tTG, celiac disease testing. What is this test? This test is used to see if you have celiac disease. It is also used to see how well people with the condition are doing.

  • anti-transglutaminase antibodies

    Anti-transglutaminase antibodies

    Anti-tissue transglutaminase. Antibodies to tissue transglutaminase (abbreviated as anti-tTG or anti-TG2) are found in patients with several conditions, including celiac disease, juvenile diabetes, inflammatory bowel disease, and various forms of arthritis.

  • tstgp - clinical: tissue transglutaminase antibodies, iga

    TSTGP - Clinical: Tissue Transglutaminase Antibodies, IgA

    In terms of serology, celiac disease is associated with a variety of autoantibodies, including endomysial, tissue transglutaminase (tTG), and deamidated gliadin antibodies. Although the IgA isotype of these antibodies usually predominates in celiac disease, individuals may also produce IgG isotypes, particularly if the individual is IgA deficient.

  • t-transglutaminase (ttg) iga - lab results explained

    t-Transglutaminase (tTG) IgA - Lab Results explained

    A tissue transglutaminase IgA (tTg-IgA) test is used to help doctors diagnose celiac disease or to see how well people with the condition are doing. What is celiac disease? Celiac disease is an autoimmune disorder in which the immune system mistakenly thinks that gluten – a protein in wheat, barley, rye, and oats – is a foreign invader.

  • celiac disease screening | celiac disease foundation

    Celiac Disease Screening | Celiac Disease Foundation

    Tissue Transglutaminase Antibodies (tTG-IgA) – the tTG-IgA test will be positive in about 98% of patients with celiac disease who are on a gluten-containing diet. The test’s sensitivity measures how correctly it identifies those with the disease.

  • blood test: tissue transglutaminase iga, igg (for parents

    Blood Test: Tissue Transglutaminase IgA, IgG (for Parents

    A tissue transglutaminase IgA (tTg-IgA) test is used to help doctors diagnose celiac disease. Celiac disease is an autoimmune disorder in which the immune system mistakenly thinks that gluten — a protein in wheat, barley, rye, and oats — is a foreign invader.

  • anti-transglutaminase antibodies

    Anti-transglutaminase antibodies

    Anti-tissue transglutaminase. Antibodies to tissue transglutaminase (abbreviated as anti-tTG or anti-TG2) are found in patients with several conditions, including celiac disease, juvenile diabetes, inflammatory bowel disease, and various forms of arthritis.

  • blood test: tissue transglutaminase iga, igg

    Blood Test: Tissue Transglutaminase IgA, IgG

    Blood Test: Tissue Transglutaminase IgA, IgG. What It Is. A tissue transglutaminase (tTG) IgA and/or IgG test is used as part of an evaluation for certain autoimmune conditions, most notably celiac disease. An autoimmune disease can occur when the body’s immune system mistakenly perceives a nonthreatening substance.

  • blood test: tissue transglutaminase iga, igg

    Blood Test: Tissue Transglutaminase IgA, IgG

    A tissue transglutaminase IgA (tTg-IgA) test is used to help doctors diagnose celiac disease. Celiac disease is an autoimmune disorder in which the immune system mistakenly thinks that gluten — a protein in wheat, barley, rye, and oats — is a foreign invader.

  • celiac disease screening | celiac disease foundation

    Celiac Disease Screening | Celiac Disease Foundation

    Tissue Transglutaminase Antibodies (tTG-IgA) – the tTG-IgA test will be positive in about 98% of patients with celiac disease who are on a gluten-containing diet. The test’s sensitivity measures how correctly it identifies those with the disease.

  • the function of tissue transglutaminase in celiac disease

    The function of tissue transglutaminase in celiac disease

    Tissue transglutaminase (tTG) is a calcium dependent ubiquitous enzyme which catalyses posttranslational modification of proteins and is released from cells during inflammation. tTG is suggested to exert at least two crucial roles in celiac disease: as a deamidating enzyme, that can enhance the immunostimulatory effect of gluten, and as a

  • anti-tissue transglutaminase antibody - rochester, ny

    Anti-tissue Transglutaminase Antibody - Rochester, NY

    A blood test that shows higher levels of anti-tissue transglutaminase antibodies can help your healthcare provider figure out if you have celiac disease. Why do I need this test? If you have celiac disease, you are allergic to gluten. Gluten is the protein found in wheat, rye, and barley. Celiac disease is an autoimmune disorder.

  • tissue transglutaminase

    Tissue transglutaminase

    Anti-transglutaminase antibodies result in a form of gluten sensitivity in which a cellular response to Triticeae glutens that are crosslinked to tTG are able to stimulate transglutaminase specific B-cell responses that eventually result in the production of anti-transglutaminase antibodies IgA and IgG.

  • celiac disease antibody tests | lab tests

    Celiac Disease Antibody Tests | Lab Tests

    Tissue transglutaminase antibody (tTG), IgA class — the primary test ordered to screen for celiac disease. It is the most sensitive and specific blood test for celiac disease and is the single test preferred by the American College of Gastroenterology and the American Gastroenterology Association for the detection of celiac disease in those

  • 164640: tissue transglutaminase (ttg), iga | labcorp

    164640: Tissue Transglutaminase (tTG), IgA | LabCorp

    Studies have demonstrated that IgA endomysial antibody tests have >99% specificity for gluten-sensitive enteropathy. 1 Recently, the endomysial antigen has been identified as the protein cross-linking enzyme known as tissue transglutaminase (tTG). 2

  • tissue transglutaminase

    Tissue Transglutaminase

    Anti– tissue transglutaminase (TTG) immunoglobulin A (IgA) and anti–endomysial antibodies (EMA) IgA have been demonstrated to be highly sensitive and specific for celiac disease. Because of low cost, ease of test performance, and reliability, TTG is currently recommended for initial screening of celiac disease.

  • ttga - clinical: tissue transglutaminase antibody, iga, serum

    TTGA - Clinical: Tissue Transglutaminase Antibody, IgA, Serum

    If total IgA is normal and tissue transglutaminase (tTG)-IgA is negative, there is a low probability of the patient having celiac disease and a biopsy may not be necessary. If serology is negative or there is substantial clinical doubt remaining, then further investigation should be performed with endoscopy and bowel biopsy.

  • celiac disease antibody tests | lab tests

    Celiac Disease Antibody Tests | Lab Tests

    Immunoglobulin A (IgA) anti-tissue transglutaminase (tTG) antibody is the preferred single test for the serologic diagnosis of CD in individuals over the age of 2 years. The IgA anti-TTG test has 95% or higher sensitivity and specificity for CD.

  • anti-tissue transglutaminase antibody - rochester, ny

    Anti-tissue Transglutaminase Antibody - Rochester, NY

    The higher the levels of anti-tissue transglutaminase antibodies in your blood, the more likely it is that you have it or a related disorder. Younger children are an exception to this rule. A test may come back negative even if the child has celiac disease.

  • tissue transglutaminase levels above 100 u/ml and celiac

    Tissue transglutaminase levels above 100 U/mL and celiac

    Serologically, the immune reaction to gluten can be detected by measuring disease-specific antibodies, the anti-endomysium antibodies (EMA) and the anti-tissue-transglutaminase antibodies (tTGA). In clinical practice, the measurement of these antibodies is used to screen for CD, as they are highly sensitive and specific.

  • anti-transglutaminase antibodies

    Anti-transglutaminase antibodies

    Anti-tissue transglutaminase. Antibodies to tissue transglutaminase (abbreviated as anti-tTG or anti-TG2) are found in patients with several conditions, including celiac disease, juvenile diabetes, inflammatory bowel disease, and various forms of arthritis.

  • anti-tissue transglutaminase antibody test - reference range

    Anti-tissue Transglutaminase Antibody Test - Reference Range

    The higher the levels of anti-tissue transglutaminase antibodies in your blood, the more likely it is that you have it or a related disorder. Younger children are an exception to this rule. A test may come back negative even if the child has celiac disease. But other tests can give a proper diagnosis.

  • testing - celiac disease foundation

    Testing - Celiac Disease Foundation

    Tissue Transglutaminase Antibodies (tTG-IgA) – the tTG-IgA test will be positive in about 98% of patients with celiac disease who are on a gluten-containing diet. The test’s sensitivity measures how correctly it identifies those with the disease. The same test will come back negative in about 95% of healthy people without celiac disease.

  • blood test: tissue transglutaminase iga, igg (for parents

    Blood Test: Tissue Transglutaminase IgA, IgG (for Parents

    A tissue transglutaminase IgA (tTg-IgA) test is used to help doctors diagnose celiac disease. Celiac disease is an autoimmune disorder in which the immune system mistakenly thinks that gluten — a protein in wheat, barley, rye, and oats — is a foreign invader.

  • test id: tstgp tissue transglutaminase antibodies, iga

    Test ID: TSTGP Tissue Transglutaminase Antibodies, IgA

    The finding of tissue transglutaminase (tTG) IgA antibodies is specific for celiac disease and possibly for dermatitis herpetiformis. For individuals with moderately to strongly positive results, a diagnosis of celiac disease is likely and the patient should undergo biopsy to confirm the diagnosis.

  • 164640: tissue transglutaminase (ttg), iga | labcorp

    164640: Tissue Transglutaminase (tTG), IgA | LabCorp

    Studies have demonstrated that IgA endomysial antibody tests have >99% specificity for gluten-sensitive enteropathy. 1 Recently, the endomysial antigen has been identified as the protein cross-linking enzyme known as tissue transglutaminase (tTG). 2

  • blood test: tissue transglutaminase iga, igg

    Blood Test: Tissue Transglutaminase IgA, IgG

    A tissue transglutaminase IgA (tTg-IgA) test is used to help doctors diagnose celiac disease. Celiac disease is an autoimmune disorder in which the immune system mistakenly thinks that gluten — a protein in wheat, barley, rye, and oats — is a foreign invader.

  • celiac disease antibody tests | lab tests

    Celiac Disease Antibody Tests | Lab Tests

    Tissue transglutaminase antibody (tTG), IgA class — the primary test ordered to screen for celiac disease. It is the most sensitive and specific blood test for celiac disease and is the single test preferred by the American College of Gastroenterology and the American Gastroenterology Association for the detection of celiac disease in those

  • tissue transglutaminase expression is necessary for adhesion

    Tissue transglutaminase expression is necessary for adhesion

    Tissue transglutaminase (TG2) is the ubiquitously expressed member of transglutaminase family and shown to play a critical role in the development and progression of drug resistance malignancies. We have previously showed the association of TG2 upregulation with progression and metastasis of renal cell carcinoma (RCC) and low disease-free survival.

  • tissue transglutaminase levels above 100 u/ml and celiac

    Tissue transglutaminase levels above 100 U/mL and celiac

    Antibodies directed against the endomysium are actually directed against tissue-transglutaminase. Peer review The authors present data from a prospective study on application of new cut-off values for diagnosing celiac disease in a population of children with high pre-test likelihood of disease.

  • the stem cell/cancer stem cell marker aldh1a3 regulates the

    The Stem cell/cancer Stem Cell Marker ALDH1A3 Regulates the

    Tissue transglutaminase (tTG), a dual-function enzyme with GTP-binding and acyltransferase activities, has been implicated in the survival and chemotherapy resistance of aggressive cancer cells and cancer stem cells, including glioma stem cells (GSCs). Using a model system comprising two distinct su …

  • tissue transglutaminase in hcv infection | cell death

    Tissue transglutaminase in HCV infection | Cell Death

    The focus of this letter will be on one member of this gene family, the ‘tissue’ transglutaminase (tTG; E.C. 2.3.2.13) or type-II transglutaminase or transglutaminase C.

  • tissue transglutaminase

    Tissue Transglutaminase

    Transglutaminase 2 (TG2 or tissue transglutaminase) is a highly complex multifunctional protein that acts as transglutaminase, GTPase/ATPase, protein disulfide isomerase, and protein kinase. Moreover, TG2 has many well-documented nonenzymatic functions that are based on its noncovalent interactions with multiple cellular proteins.

  • increased expression of tissue transglutaminase in pancreatic

    Increased Expression of Tissue Transglutaminase in Pancreatic

    To further evaluate the significance of our in vitro observations that TG2 expression results in gemcitabine resistance and invasive potential, we examined the expression levels of TG2 in a human tissue microarray containing 75 PDAC tissue samples. We found high basal levels of TG2 expression in 42 of the 75 (56%) tumor samples studied ( Fig

  • atorvastatin induces tissue transglutaminase in human

    Atorvastatin induces tissue transglutaminase in human

    Tissue transglutaminase (tTgase) contributes to the organisation of the basement membrane and is therefore thought to be important for the integrity and stability of the vessel wall. In the present study, we hypothesised that the HMG-CoA reductase inhibitor atorvastatin may up-regulate the tTgase expression in endothelial cells and thereby

  • tissue transglutaminase in hcv infection | cell death

    Tissue transglutaminase in HCV infection | Cell Death

    The focus of this letter will be on one member of this gene family, the ‘tissue’ transglutaminase (tTG; E.C. 2.3.2.13) or type-II transglutaminase or transglutaminase C.

  • overexpression of tissue transglutaminase leads to

    Overexpression of Tissue Transglutaminase Leads to

    Introduction. Tissue transglutaminase (TG2; EC 2.3.2.13) is an important member of the transglutaminase family of enzymes that catalyze Ca 2+-dependent post-translational modification of proteins by inserting irreversible ε(γ-glutamyl)lysine cross-links between substrate proteins ( 1– 3).

  • tissue transglutaminase

    Tissue Transglutaminase

    Transglutaminase 2 (TG2 or tissue transglutaminase) is a highly complex multifunctional protein that acts as transglutaminase, GTPase/ATPase, protein disulfide isomerase, and protein kinase. Moreover, TG2 has many well-documented nonenzymatic functions that are based on its noncovalent interactions with multiple cellular proteins.

  • contribution of tissue transglutaminase to the severity

    Contribution of tissue transglutaminase to the severity

    Tissue transglutaminase (tTG)-regulating IL-13 plays an important role in the pathogenesis of liver fibrosis resulting from Schistosoma japonicum (Sj) infection. IL-33 and its receptor ST2 are involved in Th2-biased immune responses through the release of IL-5 and IL-13 and subsequent hepatic granuloma pathology induced by Sj infection. However, the relationship between tTG, IL-33/ST2, and

  • transglutaminase activity in the hematopoietic tissue of a

    Transglutaminase activity in the hematopoietic tissue of a

    In the tiger shrimp P. monodon high expression of shrimp transglutaminase (shrimp TG) was detected in young hemocytes in the hematopoietic tissue. In situ hybridization, especially dividing cells and cells with more condensed cytoplasm always yielded stronger TG signals [ 17 ].

  • tissue transglutaminase-interleukin-6 axis facilitates

    Tissue transglutaminase-interleukin-6 axis facilitates

    Inflammation has recently been implicated in cancer formation and progression. As tissue transglutaminase (TG2) has been associated with both inflammatory signaling and tumor cell behavior, we propose that TG2 may be an important link inducing interleukin-6 (IL-6)-mediated cancer cell aggressiveness, including cancer stem cell-like characteristics and distant hematogenous metastasis.