clinical pharmacokinetics of oxazepam and lorazepam
Clinical Pharmacokinetics of Oxazepam and Lorazepam
Oxazepam and lorazepam are 3-hydroxy benzodiazepine derivatives used as sedatives and anxiolytics. The major metabolic pathway for both compounds involves conjugation to glucuronic acid at the 3-position, followed by urinary excretion of the inactive glucuronide metabolite. Oxazepam has been administered to humans by the oral route only. Usual ranges for kinetic parameters are: elimination
Clinical pharmacokinetics of oxazepam and lorazepam.
Oxazepam and lorazepam are 3-hydroxy benzodiazepine derivatives used as sedatives and anxiolytics. The major metabolic pathway for both compounds involves conjugation to glucuronic acid at the 3-position, followed by urinary excretion of the inactive glucuronide metabolite. Oxazepam has been administered to humans by the oral route only.
Clinical pharmacokinetics of lorazepam - Greenblatt - 1976
Clinical pharmacokinetics of lorazepam. Cimetidine spares the glucuronidation of lorazepam and oxazepam, Gastroenterology, 10.1016/0016-5085(80)90450-3,
Clinical pharmacokinetics of lorazepam: a review
The clinical pharmacokinetics of lorazepam, a 3-hydroxy, 1,4-benzodiazepine, indicate that it is rapidly and readily absorbed, reaching peak concentrations in the blood proportional to the dose approximately 2 hours after oral administration. Blood levels decline thereafter, with an elimination half-life of about 12 hrs.
Lorazepam vs Oxazepam Comparison - Drugs.com
Compare Lorazepam vs Oxazepam head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Lorazepam rated 8.0/10 vs Oxazepam rated 8.3/10 in overall patient satisfaction.
Clinical Pharmacokinetics of Lorazepam. III. Intravenous
Divisions of Research and of Clinical Research and Development, Wyeth Laboratories, Radnor, Penn. Supported in part by Grant MH‐12279 from the United States Public Health Service (Drs. Greenblatt and Shader). Clinical Pharmacology Unit, Massachusetts General Hospital, Boston, Mass. 02114.Search for more papers by this author
Bioavailability and pharmacokinetics of oxazepam. - Abstract
Chinnery R, Sundwall A (1978) Pharmacodynamic, pharmacokinetic and clinical aspects on oxazepam and related benzodiazepines. Acta Psychiatr Scand 274 [Suppl]: 1-128 Wretlind M, Pilbrant A, Sundwall A, Vessman J (1977) Disposition of three benzodiazepines after single oral administration in man.
Pharmacokinetics and pharmacodynamics of oxazepam
Abstract. 1. The effect of severe hypothyroidism on the pharmacokinetics and pharmacodynamics of oxazepam 15 mg given orally (n = 10) and the metabolism of paracetamol 750 mg given intravenously (n = 8) was investigated before and after treatment with levothyroxine.
Useful Information about the pharmacokinetics
Greenblatt DJ: Clinical pharmacokinetics of oxazepam and lorazepam. Clin Pharmacokinet 1981; 6: 89–105Greenblatt, DJ Aaltonen L, Kanto J, Arola M, Iisalo E, Pakkanen A: Effect of age and cardiopulmonary bypass on the pharmacokinetics of lorazepam.
Oxazepam pharmacokinetics in thyroid disease. - Scott - 1984
The pharmacokinetics of oxazepam, a drug mainly eliminated by a single step glucuronidation reaction, were studied in seven hyperthyroid and six hypothyroid patients before and after treatment. Oxazepam elimination half‐life was shorter and apparent oral clearance higher in untreated hyperthyroid patients than after treatment.
Oxazepam is similar to lorazepam in this respect. Preferential storage of oxazepam occurs in some organs, including the heart of the neonate. Absorption by any administered route and the risk of accumulation is significantly increased in the neonate, and withdrawal of oxazepam during pregnancy and breast feeding is recommended, as oxazepam is
Clinical Pharmacology and Therapeutics of Benzodiazepines
Clinical Pharmacology and Therapeutics of Benzodiazepines Article (PDF Available) in Canadian Medical Association journal 118(12):1533-8 · July 1978 with 616 Reads How we measure 'reads'